The INR invented and pioneered local anti-TNF treatment for chronic spinal pain (low back pain, neck pain, or sciatica) in 1999 and is established as the world leader in anti-TNF treatment for pain. The INR has more than a decade of favorable clinical experience in this area, and has treated more than 3,000 patients from all over the world.

The INR anti-TNF treatment is a patented treatment method available exclusively through medical providers trained at the INR.  The INR is located in Boca Raton, Florida. Contact info

Novel methods of administration of patented drugs are patentable. The Founder of the INR, Edward Tobinick MD, invented novel methods of administration of anti-TNF molecules for the treatment of neurological disorders more than a decade ago. These methods have demonstrated clinical utility for the treatment of a variety of neurological disorders, including not only spinal pain (low back pain, neck pain, and sciatica) but also other neurological disorders, such as Alzheimer’ disease and stroke, that are associated with excess TNF[1-12].